Table 1 Twenty proteins constitute the common secretome of P. acnes.
From: Proteomic identification of secreted proteins of Propionibacterium acnes
Gene ID | Updated annotation | Protein family/domains/origin of closest ortholog | Secretion signala | Phylo-type | Semi-quantificationb/comments |
|---|---|---|---|---|---|
PPA0532 | conserved hypothetical protein | Corynebacterium | SP, TAT | IA, IB, III | ++ |
PPA0533 | conserved hypothetical protein | Corynebacterium | SP | IA, IB, II, III | + |
PPA0534 | conserved hypothetical protein | Corynebacterium | SP | IA, IB | + |
PPA0598 | putative protease | peptidase S8/S53 superfamily; Arthrobacter | SP, (TAT) | IA, IB | + |
PPA0644 | putative endo-glycoceramidase | cellulase, glycoside hydrolase family 5; Corynebacterium | (SP), TAT | IA, IB, III | ++/42% identity to PPA2106 |
PPA0687 | CAMP2 | CAMP factor superfamily; Mobiluncus curtisii, Streptococcus | SP | IA, IB, II, III | +++ |
PPA0721 | putative invasion-associated protein; NlpC/P60 family | NlpC/P60 family; Kribbella flavida, Streptomyces | SP, TAT | IA, IB, II, III | +++/NlpC/P60 is found in cell wall hydrolases |
PPA0816 | glyceraldehyde 3-phosphate dehydrogenase | GAPDH | no | IB, II, III | + |
PPA1310 | putative protease | PDZ superfamily; Kribbella flavida, Streptomyces | Internal SP (wrong N-terminus) | IA, IB, II, III | +/PDZ is a signaling domain |
PPA1498 | putative phosphoesterase | metallo-dependent phosphatase superfamily; Rhodococcus | TAT | IA, IB, II | + |
PPA1662 | putative lysozyme | CH-type (chalaropsis-type) lysozyme, glycoside hydrolase family 25; Streptomyces | SP, TAT | IB, II, III | +++ |
PPA1715 | hypothetical protein, specific to P. acnes | SP | IA, IB | +/17 PT repeats | |
PPA1939 | hypothetical protein, specific to P. acnes | SP | IA, IB, II, III | +++ | |
PPA2097 | putative 5'-nucleotidase, metallo-phosphoesterase | UshA (5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases); Jonesia denitrificans | SP, TAT | IB, II | + |
PPA2105 | triacylglycerol lipase | lipase class 2, esterase/lipase superfamily; Rhodococcus | SP | IA, IB, II, III | ++ |
PPA2106 | putative endoglycoceramidase | cellulase, glycoside hydrolase family 5; Nocardioides | SP, (TAT) | IA, IB, II, III | +/42% identity to PPA0644 |
PPA2142 | putative lysophospholipase | alpha/beta-hydrolase superfamily, PldB; Corynebacterium | SP, TAT | IB, II | + |
PPA2164 | putative beta-N-acetyl-glucosaminidase | glycoside hydrolase family 3; Arthrobacter | SP | IA, IB, II | ++ |
PPA2175 | hypothetical protein, with SH3 and RlpA domains, specific to P. acnes | SH3 (type 3) domain; peptidoglycan-binding domain; C-terminus: DPBB_1 (RlpA-like double-psi beta-barrel) | SP, TAT | IB, II | +++/SH3: Src homology 3 domain |
PPA2239 | putative peptidase/glycosyl hydrolase | DUF348 superfamily; G5 domain; C-terminus: DPBB_1 (RlpA-like double-psi beta-barrel); Janibacter | SP | IA, IB, II, III | ++/G5: a potential N-acetylglucosamine recognition domain |