Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females

Table 2 Demographic and histologic characteristics of H. pylori-infected patients with single nucleotide polymorphism analysis (n = 470)

	Gastritis	Duodenal ulcer	Gastric ulcer	p value
Parameters	(n = 265)	(n = 118)	(n = 87)
Age, mean (SD) (yr)	46.9 (13.7)	47.6 (14.0)	47.8 (11.7)	NS
Gender, n (%)
Female: Male	183 (69.1): 82 (30.9)	57 (48.3) : 61 (51.7)	36 (41.4) : 51 (58.6)	p ^a < 0.05; p ^b < 0.05
Histology score, mean (SD)
(Antrum)
AIS (range 1-3)	1.18 (0.99)	1.39 (0.95)	0.99 (1.03)	p ^c < 0.05
CIS (range 0-3)	2.34 (1.01)	2.56 (0.89)	2.05 (1.17)	p ^a < 0.05; p ^b < 0.05; p ^c < 0.05
(Corpus)
AIS (range 1-3)	0.85 (0.99)	0.72 (0.95)	0.86 (1.06)	NS
CIS (range 0-3)	2.24 (0.86)	2.15 (0.83)	2.13 (0.89)	NS

Abbreviations: AIS, acute inflammation; CIS, chronic inflammation. The p value was determined by t test (age), χ² test (gender) or Mann-Whitney U test (histology score). ^a indicated significance with p < 0.05 of such parameter between gastritis and duodenal ulcer; ^b between gastritis and gastric ulcer; ^c between duodenal ulcer and gastric ulcer. NS: no significant difference.

ISSN: 1471-2180