Skip to main content

Advertisement

Table 4 Variation in human proteins

From: Genetic variation in Staphylococcus aureus surface and immune evasion genes is lineage associated: implications for vaccine design and host-pathogen interactions

Ligand Gene NCBIGeneID Variable amino acid sites Proportion of variable sites Characterised interacting S. aureus protein(s)
Elastin eln 2006 40, 71,165, 298, 311, 398, 422, 463, 494, 503, 544, 581, 651, 711 0.019 EbpS, FnBPA
Fibrinogen/Fibrin fga 2243 6, 331b, 392, 446, 456, 507, 729 0.010 ClfB, FnBPB, Ebh, IsdA,
  fgb 2244 2, 86,100,170,192, 265, 398, 478 0.016 Efb,
  fgg 2266 12,14, 25, 54, 77, 87, 89,113,114,132,140,177,191, 219, 410ac 0.033 ClfA, FnBPA
Fibronectin fn-1 2335 15, 251c, 352, 759, 817, 984,1044,1103,1558, 2195, 2212, 2261, 2275, 2281 0.006 FnBPA, FnBPB,
Prothrombin f2 2147 165, 200, 272, 386 0.006 VWbp
Vitronectin vtn 7448 122, 268, 400 0.006 Unknown protein [118]
von Willebrand factor vwf 7450 137, 318, 325d, 471, 484, 653, 740, 817, 852, 885,1380,1381,1435,1472,1565,1569, 2126, 2178, 2281, 2342, 2561, 2705 0.008 VWbp Spa
  1. a residues located in ClfA binding region [61].
  2. b residues located in ClfB binding region [64].
  3. c residues located in FnBPA binding region [91, 92].