Figure 4

Prevention of primary HSV-2 disease in guinea pigs immunized with CJ9-gD. After challenge with wild-type HSV-2, individual guinea pigs described in legend of Fig. 3 were observed during a 60-day follow-up period for the incidence of genital and disseminated HSV-2 disease using the following score: 0 = no disease; 1 = redness or swelling; 2 = a few small vesicles; 3 = several large vesicles; 4 = several large ulcers with maceration; 5 = paralysis; and 6 = death. Presented is the disease score for the first 15 days after challenge (A.) and the percentage of survival until day 60 after challenge (B.).