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Table 2 Expression of "cell wall stress stimulon" genes: comparison of current study with published results in the SAMMD.

From: Revealing fosfomycin primary effect on Staphylococcus aureus transcriptome: modulation of cell envelope biosynthesis and phosphoenolpyruvate induced starvation

N315 LOCUSa Gene Nameb Expression fold changec Gene Product Descriptione TIGR Functional Group
   t10c1 t20c1 t40c1 t10c4 t20c4 t40c4 Cell wall active antibioticsd   
SA0909 fmt    2.65   1.83 3.23 + Fmt, autolysis and methicillin resistant-related protein Cell envelope
SA1549     1.38   0.63 1.87 + hypothetical protein, similar to serine proteinase Protein fate
SA1659 prsA    1.57   0.94 1.89 + peptidyl-prolyl cis/trans isomerase homolog Protein fate
SA1691 sgtB   0.37 2.37   1.31 3.14 + hypothetical protein, similar to penicillin-binding protein 1A/1B Cell envelope
SA1701 vraS   0.28 2.05   1.21 2.93 + two-component sensor histidine kinase Cellular processes
SA1702     2.25   1.29 3.34 + conserved hypothetical protein Unclassified
SA1703     2.63   1.47 3.54 + hypothetical protein Unclassified
SA1712     0.69   0.41 1.60 + conserved hypothetical protein Unclassified
SA1926 murZ    0.94   0.51 1.45 + UDP-N-acetylglucosamine 1-carboxylvinyl transferase 2 Cell envelope
SA2103     1.58   0.87 2.11 + hypothetical protein, similar to lyt divergon expression Regulatory functions
SA2146 tcaA   0.27 2.07   1.27 2.69 + TcaA protein Energy metabolism
SA2220     0.95   0.47 1.48 + hypothetical protein Energy metabolism
SA2221     1.92   0.96 2.59 + hypothetical protein Unclassified
SA2297        0.37 + hypothetical protein, similar to GTP-pyrophosphokinase Unclassified
SA2343   -0.73 2.11 7.08   5.50 7.62 + hypothetical protein Unclassified
SA0423     -0.47    -1.34 - hypothetical protein, similar to autolysin (N-acetylmuramoyl-L-alanine amidase) Unclassified
SA0905 atl    -0.54    -1.24 - autolysin Cell envelope
     -0.51    -1.19    
  1. a S. aureus N315 genome ORF locus.
  2. b Previously described gene name.
  3. c Gene expression log2 fold change of treated vs. non-treated bacteria. Abbreviations correspond to experimental design points.
  4. d Previously reported expression increase (+) or decrease (-) of cell-wall-antibiotic treated vs. non-treated bacteria.
  5. e Gene product functional annotation.
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BMC Microbiology

ISSN: 1471-2180

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