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Table 2 Expression of "cell wall stress stimulon" genes: comparison of current study with published results in the SAMMD.

From: Revealing fosfomycin primary effect on Staphylococcus aureus transcriptome: modulation of cell envelope biosynthesis and phosphoenolpyruvate induced starvation

N315 LOCUSa

Gene Nameb

Expression fold changec

Gene Product Descriptione

TIGR Functional Group

  

t10c1

t20c1

t40c1

t10c4

t20c4

t40c4

Cell wall active antibioticsd

  

SA0909

fmt

  

2.65

 

1.83

3.23

+

Fmt, autolysis and methicillin resistant-related protein

Cell envelope

SA1549

   

1.38

 

0.63

1.87

+

hypothetical protein, similar to serine proteinase

Protein fate

SA1659

prsA

  

1.57

 

0.94

1.89

+

peptidyl-prolyl cis/trans isomerase homolog

Protein fate

SA1691

sgtB

 

0.37

2.37

 

1.31

3.14

+

hypothetical protein, similar to penicillin-binding protein 1A/1B

Cell envelope

SA1701

vraS

 

0.28

2.05

 

1.21

2.93

+

two-component sensor histidine kinase

Cellular processes

SA1702

   

2.25

 

1.29

3.34

+

conserved hypothetical protein

Unclassified

SA1703

   

2.63

 

1.47

3.54

+

hypothetical protein

Unclassified

SA1712

   

0.69

 

0.41

1.60

+

conserved hypothetical protein

Unclassified

SA1926

murZ

  

0.94

 

0.51

1.45

+

UDP-N-acetylglucosamine 1-carboxylvinyl transferase 2

Cell envelope

SA2103

   

1.58

 

0.87

2.11

+

hypothetical protein, similar to lyt divergon expression

Regulatory functions

SA2146

tcaA

 

0.27

2.07

 

1.27

2.69

+

TcaA protein

Energy metabolism

SA2220

   

0.95

 

0.47

1.48

+

hypothetical protein

Energy metabolism

SA2221

   

1.92

 

0.96

2.59

+

hypothetical protein

Unclassified

SA2297

      

0.37

+

hypothetical protein, similar to GTP-pyrophosphokinase

Unclassified

SA2343

 

-0.73

2.11

7.08

 

5.50

7.62

+

hypothetical protein

Unclassified

SA0423

   

-0.47

  

-1.34

-

hypothetical protein, similar to autolysin (N-acetylmuramoyl-L-alanine amidase)

Unclassified

SA0905

atl

  

-0.54

  

-1.24

-

autolysin

Cell envelope

    

-0.51

  

-1.19

   
  1. a S. aureus N315 genome ORF locus.
  2. b Previously described gene name.
  3. c Gene expression log2 fold change of treated vs. non-treated bacteria. Abbreviations correspond to experimental design points.
  4. d Previously reported expression increase (+) or decrease (-) of cell-wall-antibiotic treated vs. non-treated bacteria.
  5. e Gene product functional annotation.