Revealing fosfomycin primary effect on Staphylococcus aureus transcriptome: modulation of cell envelope biosynthesis and phosphoenolpyruvate induced starvation

BMC Microbiology

Table 2 Expression of "cell wall stress stimulon" genes: comparison of current study with published results in the SAMMD.

N315 LOCUS^a	Gene Name^b	Expression fold change^c							Gene Product Description^e	TIGR Functional Group
		t10c1	t20c1	t40c1	t10c4	t20c4	t40c4	Cell wall active antibiotics^d
SA0909	fmt			2.65		1.83	3.23	+	Fmt, autolysis and methicillin resistant-related protein	Cell envelope
SA1549				1.38		0.63	1.87	+	hypothetical protein, similar to serine proteinase	Protein fate
SA1659	prsA			1.57		0.94	1.89	+	peptidyl-prolyl cis/trans isomerase homolog	Protein fate
SA1691	sgtB		0.37	2.37		1.31	3.14	+	hypothetical protein, similar to penicillin-binding protein 1A/1B	Cell envelope
SA1701	vraS		0.28	2.05		1.21	2.93	+	two-component sensor histidine kinase	Cellular processes
SA1702				2.25		1.29	3.34	+	conserved hypothetical protein	Unclassified
SA1703				2.63		1.47	3.54	+	hypothetical protein	Unclassified
SA1712				0.69		0.41	1.60	+	conserved hypothetical protein	Unclassified
SA1926	murZ			0.94		0.51	1.45	+	UDP-N-acetylglucosamine 1-carboxylvinyl transferase 2	Cell envelope
SA2103				1.58		0.87	2.11	+	hypothetical protein, similar to lyt divergon expression	Regulatory functions
SA2146	tcaA		0.27	2.07		1.27	2.69	+	TcaA protein	Energy metabolism
SA2220				0.95		0.47	1.48	+	hypothetical protein	Energy metabolism
SA2221				1.92		0.96	2.59	+	hypothetical protein	Unclassified
SA2297							0.37	+	hypothetical protein, similar to GTP-pyrophosphokinase	Unclassified
SA2343		-0.73	2.11	7.08		5.50	7.62	+	hypothetical protein	Unclassified
SA0423				-0.47			-1.34	-	hypothetical protein, similar to autolysin (N-acetylmuramoyl-L-alanine amidase)	Unclassified
SA0905	atl			-0.54			-1.24	-	autolysin	Cell envelope
				-0.51			-1.19

^a S. aureus N315 genome ORF locus.
^b Previously described gene name.
^c Gene expression log₂ fold change of treated vs. non-treated bacteria. Abbreviations correspond to experimental design points.
^d Previously reported expression increase (+) or decrease (-) of cell-wall-antibiotic treated vs. non-treated bacteria.
^e Gene product functional annotation.