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Table 1 List of genes that are upregulated upon P. acnes infection.

From: Propionibacterium acnes infection induces upregulation of inflammatory genes and cytokine secretion in prostate epithelial cells

Gene name Description Fold upregulation
CCL2 Chemokine (C-C motif) ligand 2 41
CSF2 Colony stimulating factor 2 (granulocyte-macrophage) 139
CSF3 Colony stimulating factor 3 (granulocyte) 39
CXCL10 Chemokine (C-X-C motif) ligand 10 107
IFNB1 Interferon, beta 1, fibroblast 12
IL1A Interleukin 1, alpha 12
IL6 Interleukin 6 (interferon, beta 2) 34
IL8 Interleukin 8 336
IRAK2 Interleukin-1 receptor-associated kinase 2 11
IRF1 Interferon regulatory factor 1 12
JUN Jun oncogene 10
LTA Lymphotoxin alpha (TNF superfamily, member 1) 5
NFKB2 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 8
NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 6
REL V-rel reticuloendotheliosis viral oncogene homolog 4
RELA V-rel reticuloendotheliosis viral oncogene homolog A, 2
RIPK2 Receptor-interacting serine-threonine kinase 2 4
TLR2 Toll-like receptor 2 3
TNF Tumor necrosis factor (TNF superfamily, member 2) 53
TICAM1 Toll-like receptor adaptor molecule 1 3
  1. Semiconfluent RWPE-1 monocell-layers were infected with P. acnes at a MOI of 16:1. After 24 h infection, the cells were harvested, mRNA was collected and cDNA was prepared. The cDNA corresponding to 84 inflammation-associated genes was quantified with qRT-PCR and compared with cDNA prepared from non-infected cells. Inclusion criteria: > 2-fold up-regulation, (p = 0.05).