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Table 6 Az Disk Inhibition Assay with Francisella transposon RND Efflux mutants.

From: Azithromycin effectiveness against intracellular infections of Francisella

 

Antibiotic No Growth Zone (mm)

F. novicida

Avg

p-value

wild-type

31.4 ± 1.0

 

ftlC

28.0 ± 3.1

0.006

tolC

33.2 ± 1.4

0.007

dsbB

30.7 ± 1.2

0.162

acrA

23.5 ± 0.7

<0.001

acrB

25.2 ± 1.1

<0.001

F. tularensis Schu S4

Avg

p-value

wild-type

25.5 ± 1.9

--------

ΔacrA

41.7 ± 2.7

0.0001

ΔacrB

35.7 ± 4.3

0.001

  1. For F. novicida RND efflux mutants, 15 ug Az discs were from Remel, while for F. tularensis Schu S4, 15 ug Az discs were from Fluka. The zone of inhibition was measured in mm.