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Table 6 Az Disk Inhibition Assay with Francisella transposon RND Efflux mutants.

From: Azithromycin effectiveness against intracellular infections of Francisella

  Antibiotic No Growth Zone (mm)
F. novicida Avg p-value
wild-type 31.4 ± 1.0  
ftlC 28.0 ± 3.1 0.006
tolC 33.2 ± 1.4 0.007
dsbB 30.7 ± 1.2 0.162
acrA 23.5 ± 0.7 <0.001
acrB 25.2 ± 1.1 <0.001
F. tularensis Schu S4 Avg p-value
wild-type 25.5 ± 1.9 --------
ΔacrA 41.7 ± 2.7 0.0001
ΔacrB 35.7 ± 4.3 0.001
  1. For F. novicida RND efflux mutants, 15 ug Az discs were from Remel, while for F. tularensis Schu S4, 15 ug Az discs were from Fluka. The zone of inhibition was measured in mm.