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Table 3 A549 cell cytotoxicity.

From: Azithromycin effectiveness against intracellular infections of Francisella

Bacteria

0 μg/ml Az

0.1 μg/ml Az

1.0 μg/ml Az

2.5 μg/ml Az

5.0 μg/ml Az

A549 cells

0 ± 3.0

2.9 ± 2.8

8.0 ± 4.0

18.3 ± 5.2

19.7 ± 9.6

F. novicida

0 ± 2.3

4.1 ± 5.0

3.3 ± 6.3

9.6 ± 5.4

17.8 ± 13.2

F. philomiragia

0 ± 1.3

0 ± 2.5

7.1 ± 4.6

1.7 ± 3.2

8.5 ± 4.1

F. tularensis LVS

0 ± 3.7

2.12 ± 5.0

4.6 ± 5.9

8.4 ± 5.1

5.2 ± 5.6

  1. Using a LDH release assay, the cell cytotoxicity as a result of antibiotic and/or Francisella infection was determined and is indicated as a percentage (%) of total LDH released.