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Figure 6 | BMC Microbiology

Figure 6

From: Azithromycin effectiveness against intracellular infections of Francisella

Figure 6

Antibiotic treatment of Francisella -infected G. mellonella. High concentrations of antibiotics prolonged the survival of G. mellonella infected with 3 × 106 CFU Francisella. Non-infected control groups consisted of no injection, PBS injection, 25 μg/ml Az injection, or 20 μg/ml ciprofloxacin injection. All non-infected controls had similar high survival rates (data not shown for non-injected, 25 μg/ml Az injection, or 20 μg/ml ciprofloxacin injection). A) The infected control group received F. novicida injection, then PBS. A single dose of 25 μg/ml Az, given 2 hours after bacterial inoculation, was effective when compared to the infected control (p-value = 0.004). Treatment with 20 μg/ml ciprofloxacin prolonged the survival of the caterpillars compared to the control (p-value < 0.01). B) The infected control group received F. tularensis LVS injection, then PBS. A single dose of 25 μg/ml Az, given 2 hours after bacterial inoculation, was effective compared to the infected control (p-value < 0.001). Treatment with 20 μg/ml ciprofloxacin prolonged the survival of the caterpillars compared to control (p-value < 0.01). For F. tularensis LVS and F. novicida infections, survival time was longer in Az treated groups compared to ciprofloxacin treated groups (p-value < 0.02).

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