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Table 2 Genes involved in the four major AM functions affected by both dexamethasone and Pneumocystis infection

From: Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages

Gene

Pc vs. D

D. vs. N

Immune Response (16 genes)

Inflammation (15 genes)

Cell Death (22 genes)

Phagocytosis (18 genes)

Gnptg

-1.95

1.76

NA

NA

↓

NA

Fah

-1.80

1.50

NA

NA

↓

NA

Mmp12

-1.70

2.50

NA

↓

↓

↓

Dnaja1

-1.67

-3.20

NA

NA

↓

↓

Tfp1

-1.65

1.98

↓

↓

NA

↓

Bloc1s2

-1.63

1.61

NA

NA

↓

NA

Prkacb

-1.56

2.03

NA

NA

↓

NA

Alox5

-1.53

-3.07

↓

NA

↓

↓

Mgst1

-1.53

1.33

↓

↓

↓

↓

Hspa1b

-1.13

-13.90

↓

↓

↓

↓

Pld1

1.076

-1.05

NA

NA

↑

↑

Xdh

1.74

5.55

NA

NA

↑

↑

Cd14

1.85

8.10

↑

↑

↑

↑

Irf8

2.13

-1.61

↑

↑

↑

↑

Il1b

2.26

8.65

↑

↑

↑

↑

Cxcl13

2.41

4.17

↑

↑

↑

↑

C1qb

2.64

2.04

↑

↑

NA

NA

Cxcr4

3.60

-1.78

↑

↑

↑

↑

Fn1

4.20

10.19

↑

↑

↑

↑

Irf1

4.45

-1.52

↑

↑

↑

↑

Cd74

4.95

4.50

↑

↑

↑

↑

Srgn

5.34

3.39

↑

NA

↑

NA

S100a9

11.55

2.65

↑

↑

↑

↑

Spp1

11.78

-1.72

↑

↑

↑

↑

  1. Values shown are fold changes. D vs. N: expression affected by dexathamethasone (D) treatment compared to the normal control (N); Pc vs. D: expression affected by Pneumocystis (Pc) infection compared to the Dex (D) control. Up arrow (↑): up regulated by Pneumocystis infection; down arrow (↓): down regulated by Pneumocystis infection; NA: not applicable to the function.