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Table 3 List of phagosomal proteins identified by MS/MS post-infection with MAC 109 or 2D6 at different time points

From: Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages

  

MAC 109

2D6 mutant

Protein

Accession

(h)

(h)

Bacterial Uptake

number

0.5

4

24

0.5

4

24

Complement c1q tumor necrosis factor related protein 5

Q9BXJ0

x

x

  

x

 

Complement receptor 2

P20023

  

x

   

Macrophage receptor MARCO

Q9UEW3

x

x

  

x

 

Pulmonary surfactant protein D

P35247

 

x

    

Scavenger receptor with C type Lectin type 1

Q9BYH7

x

     

TNFRSF1A-associated via death domain/TRADD

Q15628

   

x

  

Tumor necrosis factor receptor member 1A/TNFRSF1A

1NCFA

     

x

Antigen Presentation & Recognition

       

Integrin alpha 1

P56199

   

x

  

Integrin alpha IIb

P08514

     

x

MHC class I

Q95ID4

     

x

MHC class II

I54427

     

x

Rab Interacting

       

EEA1

Q15075

     

x

Peroxin 5-related protein

Q81YB4

x

  

x

  

Rabaptin 5

Q15276

     

x

Cytoskeletal Proteins & Motors

       

Alpha actin

P62736

   

x

  

Ankyrin 1

Q6S8J3

   

x

  

Beta actin

Q96B34

x

  

x

  

E-MAP-115

Q14244

    

x

 

Keratin, type II cytoskeletal I

P04264

x

  

x

  

Kinesin/KIF3

O14782

     

x

Kinesin family member 26A

Q8TAZ7

x

     

L-plastin

P13796

  

x

x

  

Myosin heavy chain non-muscle type A

P35579

   

x

  

Myosin X with ATPase activity

Q9HD67

   

x

x

 

RHOC

P08134

   

x

  

TCP-1 zeta

P40227

   

x

  

Tubulin alpha

Q71U36

x

  

x

  

Tubulin alpha 2

Q13748

x

     

Tubulin alpha 3

Q71U36

x

     

Tubulin beta 2

P07437

x

  

x

  

Proteins in Biosynthetic Pathways

       

ABC transporter 2

Q9BZC7

x

     

ADP-ATP translocase

P05141

   

x

  

Aldoketo-reductase 3

Q9UFE1

    

x

 

ALG12

Q9BV10

 

x

    

ATP synthase

P06576

 

x

x

   

Fatty acid synthase

P49327

 

x

x

   

Fatty acid transporter member 1

Q6PCB7

x

     

GAPDH

P04406

  

x

   

Phosphatidyl inositol glycan class T

Q92643

  

x

   

IMP dehydrogenase

P12268

   

x

  

K-Cl co-transporter

T17231

     

x

Mitochondrial dicarboxylate carrier

Q9UBX3

   

x

  

Neutral amino acid transporter

Q15758

   

x

  

NUAK family, SNF1-like kinase 1

O60285

    

x

 

PI4KII

Q9BTU6

 

x

    

Pyruvate kinase

PS00110

x

  

x

 

x

Ribophorin II

Q5JYR7

  

x

   

Trehalose precursor

O43280

   

x

  

Transcriptional Regulators

       

Lysine-specific histone demethylase 1

O60341

 

x

    

CRSP complex subunit 2

O60244

  

x

   

CREB binding protein

Q75MY6

     

x

DEAH box polypeptide 9

Q08211

   

x

  

IFI 16

Q16666

 

x

    

Msx2-interacting protein

Q96T58

    

x

 

p-100 co-activator/SND1

Q7KZF4

    

x

 

p-300/CBP associated factor

Q92831

 

x

    

Zinc finger & BTB domain containing protein 4

Q9P1Z0

 

x

    

Zinc finger protein 588

Q9UII5

 

x

    

Zinc finger protein 43

P17038

x

     

60 S acidic ribosomal protein P2

P05387

   

x

  

60 S ribosomal protein L6

Q02878

x

  

x

  

60 S ribosomal protein L9

P32969

   

x

  

60 S ribosomal protein L14

P50914

x

     

Proteins Interacting with Signal Proteins

       

cAMP-specific 3',5'-cyclic phospho-diesterase

Q08493

x

     

Calcium & lipid binding protein/NLF2

388125

x

     

Chondroitin sulfate synthase 3

Q86Y52

     

x

CXC3C membrane-associated chemokine

P78423

   

x

  

Doublecortin & CaM kinase like-3

Q9C098

   

x

  

Dystrobrevin alpha

Q9Y4J8

     

x

Golgin subfamily A member 5

Q8TBA6

     

x

Microtubule associated-Ser/The kinase 3

O60307

     

x

Protein kinase A anchoring protein 9

Q99996

 

x

    

Protein kinase N

Q8NF44

 

x

    

Serine/theonine kinase 16

Q5U0F8

  

x

   

TER ATPase

P55072

   

x

  

Ion Channels

       

Amiloride-sensitive cation channel

Q96FT7

    

x

 

Voltage dependent-N-type calcium channel alpha 1B subunit

Q00975

     

x

Voltage dependent-T-type calcium channel alpha 1I subunit

Q9P0X4

     

x

Other Proteins

       

AFG3 like protein 2

Q9Y4W6

     

x

APBB1

O00213

   

x

  

Astrotactin 2

O75129

 

x

    

Apoptotic chromatin-condensation inducer in the nucleus

Q9UKV3

    

x

 

Clathrin heavy chain 1

Q00610

   

x

  

Ephrin B3

Q15768

x

     

48 kda histamine receptor subunit peptide 4

AAB34251

  

x

   

HSP 60

P10809

   

x

  

HSP 90

P07900

   

x

  

Importin alpha 2

P52292

   

x

  

Interferon regulatory factor 6

O14896

     

x

LRCH4/Ligand binding receptor

O75427

     

x

NADPH oxidase activator 1

Q2TAM1

     

x

Protein disulfide-isomerase A6

P07237

x

  

x

  

p-53-associated parkin-like cytoplasmic protein/PARC

Q8IWT3

    

x

 

Serine protease inhibitor

Q9NQ38

 

x

    

Vitrin

Q6UX17

     

x

14-3-3 protein/Tyrosine 3-monoxygenase

P62258

   

x

  

Proteins with Unknown Function

       

Hypothetical protein DKFZp434A128

T34567

     

x

Hypothetical protein LOC136288

Q8NEG2

     

x

Hypothetical protein KIA1783

Q96JP2

     

x

Hypothetical protein KIAA1783

Q96JP2

     

x

Hypothetical protein FLJ32795

Q96M63

    

x

 

Hypothetical protein FLJ42875

Q8N6L5

    

x

 

Hypothetical protein FLJ45491

Q6ZSI8

  

x

   

Hypothetical protein DKFZp434G131

Q9H0H4

 

x

    

Hypothetical protein FLJ46534

Q6ZR97

x

     

Hypothetical protein FLJ00361

Q8NF40

x

     
  1. Complemented 2D6 mutant had similar results to the wild-type bacterium. Y = Yes; N = No
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BMC Microbiology

ISSN: 1471-2180

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