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Table 1 Differential macrophage gene expression in M. avium 109 and 2D6 mutant

From: Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages

Gene Gene Bank ID Name Function Fold induction (± SD) p value <0.05
APBA2 AB014719 Amyloid beta (A4) precursor protein binding Signal transduction 10.7 ± 2.3 Y
CYP4F2 U02388 Cytochrome P450 Inactivation & degradation of leukotriene B4 2.6 ± 0.9 Y
DGKA AF064767 Diacylglycerol kinase alpha Intracellular signaling 2.3 ± 0.4 Y
DGKD D63479 Diacylglycerol kinase delta Phosphatidylinositol signaling 6.7 ± 1.2 Y
DYNC1H1 AB002323 Cytosolic dyenin heavy chain Microtubule reorganization 17.4 ± 3.1 Y
GPD2 NM_000408 Glycerol-3-phosphate dehydrogenase 2 Glycerol-3-phosphate metabolism 3.5 ± 0.4 Y
GRK4 NM_005307 G-protein coupled receptor kinase 4 Regulation of G-protein coupled receptor protein signaling 3.5 ± 0.6 Y
HIPK3 AF004849 Homeodomain interacting protein kinase 3 Inhibition of apoptosis 2.05 ± 0.3 Y
INPP1 NM_002194 Inositol polyphosphate-1-phosphatase Phosphatidylinositol signaling 2.0 ± 0.4 Y
ITK D13720 IL2-inducible T-cell kinase T-cell proliferation & differentiation 2.4 ± 0.4 Y
LCK M36881 Lymphocyte-specific protein tyrosine kinase Intracellular signaling 3.5 ± 0.7 Y
NFKB1 M58603 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Transcriptional regulator 2.3 ± 0.4 Y
PDE1C U40371 Calcium/calmodulin-dependant 3', 5'-cyclic nucleotide phosphodiesterase 1C Signal transduction 17.4 ± 1.9 Y
PKIA S76965 Protein kinase (cAmp-dependent) inhibitor alpha Negative regulation of protein kinase A 2.0 ± 0.3 Y
PPM1G Y13936 Serine/threonine protein phosphatase PP1-gamma 1 catalytic subunit Negative regulator of cell stress response/cell cycle arrest 3.2 ± 0.5 Y
PTPN11 D13540 Protein tyrosine phosphatase Intracellular signaling, cell migration 2.4 ± 0.2 Y
RGS3 AF006610 Regulator of G-protein signaling-3 Inhibition of G-protein mediated signal transduction 3.4 ± 0.3 Y
RORC U16997 RAR-related orphan receptor C Inhibition of Fas ligand and IL2 expression 3.1 ± 0.3 Y
ROR1 M97675 Receptor tyrosine kinase-like orphan receptor 1 Unknown 4.0 ± 0.4 Y
  1. Complemented 2D6 mutant had similar results to the wild-type bacterium. Y = Yes; N = No