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Table 1 MICs of trovafloxacin and ciprofloxacin alone and in combination with subinhibitory concentrations of vancomycin

From: Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae

 

MIC(mg/L)

 

WB4

WB4C

WB4T

WB4C+V

WB4T+V

Ciprofloxacin

0.5

8

>32

1

1

Ciprofloxacin +

0.5

8

>32

1

1

Vancomycin (1/4 MIC)

     

Trovafloxacin

0.12

0.25

4

0.25

0.12

Trovafloxacin +

0.12

0.25

4

0.25

0.12

Vancomycin (1/4MIC)

     

Vancomycin

0.12

0.12

0.12

0.12

0.12

  1. WB4: quinolone-susceptible but penicillin-resistant parent pneumococcus; WB4 C: ciprofloxacin-resistant derivative selected by passages on this drug; WB4 T: trovafloxacin-resistant derivative selected by passages on this drug; WB4 C+V or WB4 T+V: same as above cycled in presence of subinhibitory concentrations of vancomycin.
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BMC Microbiology

ISSN: 1471-2180

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