Skip to main content

Advertisement

Table 1 MICs of trovafloxacin and ciprofloxacin alone and in combination with subinhibitory concentrations of vancomycin

From: Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae

  MIC(mg/L)
  WB4 WB4C WB4T WB4C+V WB4T+V
Ciprofloxacin 0.5 8 >32 1 1
Ciprofloxacin + 0.5 8 >32 1 1
Vancomycin (1/4 MIC)      
Trovafloxacin 0.12 0.25 4 0.25 0.12
Trovafloxacin + 0.12 0.25 4 0.25 0.12
Vancomycin (1/4MIC)      
Vancomycin 0.12 0.12 0.12 0.12 0.12
  1. WB4: quinolone-susceptible but penicillin-resistant parent pneumococcus; WB4 C: ciprofloxacin-resistant derivative selected by passages on this drug; WB4 T: trovafloxacin-resistant derivative selected by passages on this drug; WB4 C+V or WB4 T+V: same as above cycled in presence of subinhibitory concentrations of vancomycin.