Comparison of representative PP5 TPR domains. The TPR domains of the PfPP5 are aligned with those of the other PP5 phosphatases (same as in Fig. 1) to illustrate their conserved sequence features. The structurally important hydrophobic ('b') and hydrophilic residues ('l'), and the two helices (A, B) are marked [8, 9]. Residues numbered 4, 8, 11, 20, 24, and 27 are located on the same face of their respective helices, and may be involved in the recruitment of TPR-interacting proteins [8, 9].