| |
Mutations associated with RT resistance to
|
---|
| | |
NNRTIs1
|
---|
Patients' N°3
|
Viral load4
|
by sequencing
|
by Line Probe assay
|
---|
2
|
240000
|
-
|
K70K/R
|
4
|
8900
|
-
|
L74/V75 (IR)
|
5
| |
-
|
L74/V75 (IR)
|
8
|
11000
|
-
|
F214T215 (IR)
|
12
|
160000
|
-
|
M41, T69/K70, T69/K70 (IR)
|
18
|
120000
|
-
|
T69/K70 (IR)
|
20
|
120000
|
-
|
L74/V75 (IR)
|
22
|
13000
|
-
|
L74/V75 (IR)
|
24
|
4700
|
-
|
T69/K70 (IR)
|
| | |
NNRTIs
2
|
9
|
450000
|
V108I
|
-
|
12
|
160000
|
-
|
-
|
14
|
8600
|
V118I
|
-
|
15
|
24000
|
K103N, Y181C
|
-
|
| |
Mutations associated with protease resistance (PIs)
|
|
Viral load
|
by sequential analysis
|
by LIPA
|
1
|
49000
|
V77I
|
-
|
2
|
240000
|
-
|
V82V/A
|
3
|
42000
|
L10I/L, A71V/A
|
-
|
8
|
64000
|
L63P, V77I
|
-
|
9
|
450000
|
M36I
|
-
|
11
|
16000
|
M36I
|
-
|
12
|
160000
|
L10V, M36I
|
-
|
14
|
8600
|
L10V, M36I
|
-
|
15
|
24000
|
L63P
|
-
|
16
|
1500
|
M36I
|
V82V/A
|
17
|
540000
|
L63P
|
-
|
19
|
73000
|
V77I
|
-
|
20
|
120000
|
M36I
|
-
|
23
|
61000
|
M36I
|
-
|
24
|
4700
|
L63P
|
-
|
25
|
5800
|
L63P, V77I
|
V82V/A
|
27
|
170000
|
V77I
|
-
|
- Legend: NRTIs1 nucleoside reverse transcriptase inhibitors NNRTIs2: nucleoside reverse transcriptase inhibitors 3Only patients who showed codon changes are reported; 4Viral load: N° of HIV-RNA copies/ml. 5IR: indeterminate results.