Table 1 Presence of codon substitutions associated with resistance to antiretroviral drugs (inhibitors of Reverse Transcriptase and Protease) by sequential analysis and by Line Probe assay in untreated HIV-1 patients.
| Â | Â | Mutations associated with RT resistance to | |
|---|---|---|---|
| Â | Â | Â | NNRTIs1 |
Patients' N°3 | Viral load4 | by sequencing | by Line Probe assay |
2 | 240000 | - | K70K/R |
4 | 8900 | - | L74/V75 (IR) |
5 | Â | - | L74/V75 (IR) |
8 | 11000 | - | F214T215 (IR) |
12 | 160000 | - | M41, T69/K70, T69/K70 (IR) |
18 | 120000 | - | T69/K70 (IR) |
20 | 120000 | - | L74/V75 (IR) |
22 | 13000 | - | L74/V75 (IR) |
24 | 4700 | - | T69/K70 (IR) |
| Â | Â | Â | NNRTIs 2 |
9 | 450000 | V108I | - |
12 | 160000 | - | - |
14 | 8600 | V118I | - |
15 | 24000 | K103N, Y181C | - |
| Â | Â | Mutations associated with protease resistance (PIs) | |
| Â | Viral load | by sequential analysis | by LIPA |
1 | 49000 | V77I | - |
2 | 240000 | - | V82V/A |
3 | 42000 | L10I/L, A71V/A | - |
8 | 64000 | L63P, V77I | - |
9 | 450000 | M36I | - |
11 | 16000 | M36I | - |
12 | 160000 | L10V, M36I | - |
14 | 8600 | L10V, M36I | - |
15 | 24000 | L63P | - |
16 | 1500 | M36I | V82V/A |
17 | 540000 | L63P | - |
19 | 73000 | V77I | - |
20 | 120000 | M36I | - |
23 | 61000 | M36I | - |
24 | 4700 | L63P | - |
25 | 5800 | L63P, V77I | V82V/A |
27 | 170000 | V77I | - |