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Table 1 Presence of codon substitutions associated with resistance to antiretroviral drugs (inhibitors of Reverse Transcriptase and Protease) by sequential analysis and by Line Probe assay in untreated HIV-1 patients.

From: Analysis of HIV-1 drug resistant mutations by line probe assay and direct sequencing in a cohort of therapy naive HIV-1 infected Italian patients

   Mutations associated with RT resistance to
    NNRTIs1
Patients' N°3 Viral load4 by sequencing by Line Probe assay
2 240000 - K70K/R
4 8900 - L74/V75 (IR)
5   - L74/V75 (IR)
8 11000 - F214T215 (IR)
12 160000 - M41, T69/K70, T69/K70 (IR)
18 120000 - T69/K70 (IR)
20 120000 - L74/V75 (IR)
22 13000 - L74/V75 (IR)
24 4700 - T69/K70 (IR)
    NNRTIs 2
9 450000 V108I -
12 160000 - -
14 8600 V118I -
15 24000 K103N, Y181C -
   Mutations associated with protease resistance (PIs)
  Viral load by sequential analysis by LIPA
1 49000 V77I -
2 240000 - V82V/A
3 42000 L10I/L, A71V/A -
8 64000 L63P, V77I -
9 450000 M36I -
11 16000 M36I -
12 160000 L10V, M36I -
14 8600 L10V, M36I -
15 24000 L63P -
16 1500 M36I V82V/A
17 540000 L63P -
19 73000 V77I -
20 120000 M36I -
23 61000 M36I -
24 4700 L63P -
25 5800 L63P, V77I V82V/A
27 170000 V77I -
  1. Legend: NRTIs1 nucleoside reverse transcriptase inhibitors NNRTIs2: nucleoside reverse transcriptase inhibitors 3Only patients who showed codon changes are reported; 4Viral load: N° of HIV-RNA copies/ml. 5IR: indeterminate results.
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BMC Microbiology

ISSN: 1471-2180

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