Microbial biochemistry, physiology and metabolism

Section edited by Stéphane Aymerich

This section aims to publish studies relating to microbial biochemistry, physiology and metabolism, including enzymology, metabolic pathways and regulation, growth, development and stress responses.

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  1. Research article

    In vivo characterization of an Hfq protein encoded by the Bacillus anthracis virulence plasmid pXO1

    Bacterial Hfq proteins post-transcriptionally regulate gene expression, primarily by mediating the interaction between sRNAs (small RNAs) and their target mRNAs. The role of Hfq-based regulation has been well ...

    Andrea B. Keefer, Eugenia K. Asare, Andrei P. Pomerantsev, Mahtab Moayeri, Craig Martens, Stephen F. Porcella, Susan Gottesman, Stephen H. Leppla and Catherine E. Vrentas

    BMC Microbiology 2017 17:63

    Published on: 14 March 2017

  2. Research article

    Zinc stress induces copper depletion in Acinetobacter baumannii

    The first row transition metal ions zinc and copper are essential to the survival of many organisms, although in excess these ions are associated with significant toxicity. Here, we examined the impact of zinc...

    Karl A. Hassan, Victoria G. Pederick, Liam D. H. Elbourne, Ian T. Paulsen, James C. Paton, Christopher A. McDevitt and Bart A. Eijkelkamp

    BMC Microbiology 2017 17:59

    Published on: 11 March 2017

  3. Research article

    Cloning, functional expression and characterization of a bifunctional 3-hydroxybutanal dehydrogenase /reductase involved in acetone metabolism by Desulfococcus biacutus

    The strictly anaerobic, sulfate-reducing bacterium Desulfococcus biacutus can utilize acetone as sole carbon and energy source for growth. Whereas in aerobic and nitrate-reducing bacteria acetone is activated by ...

    Jasmin Frey, Hendrik Rusche, Bernhard Schink and David Schleheck

    BMC Microbiology 2016 16:280

    Published on: 25 November 2016

  4. Research article

    Disrupting ROS-protection mechanism allows hydrogen peroxide to accumulate and oxidize Sb(III) to Sb(V) in Pseudomonas stutzeri TS44

    Microbial antimonite [Sb(III)] oxidation converts toxic Sb(III) into less toxic antimonate [Sb(V)] and plays an important role in the biogeochemical Sb cycle. Currently, little is known about the mechanisms un...

    Dan Wang, Fengqiu Zhu, Qian Wang, Christopher Rensing, Peng Yu, Jing Gong and Gejiao Wang

    BMC Microbiology 2016 16:279

    Published on: 25 November 2016

  5. Research article

    YPTB3816 of Yersinia pseudotuberculosis strain IP32953 is a virulence-related metallo-oligopeptidase

    Although bacterial peptidases are known to be produced by various microorganisms, including pathogenic bacteria, their role in bacterial physiology is not fully understood. In particular, oligopeptidases are t...

    Ali Atas, Alan M. Seddon, Donna C. Ford, Ian A. Cooper, Brendan W. Wren, Petra C. F. Oyston and Andrey V. Karlyshev

    BMC Microbiology 2016 16:282

    Published on: 25 November 2016

  6. Research article

    Pyruvate oxidase of Streptococcus pneumoniae contributes to pneumolysin release

    Streptococcus pneumoniae is one of the leading causes of community acquired pneumonia and acute otitis media. Certain aspects of S. pneumoniae’s virulence are dependent upon expression...

    Joseph C. Bryant, Ridge C. Dabbs, Katie L. Oswalt, Lindsey R. Brown, Jason W. Rosch, Keun S. Seo, Janet R. Donaldson, Larry S. McDaniel and Justin A. Thornton

    BMC Microbiology 2016 16:271

    Published on: 9 November 2016

  7. Research article

    Bacillus subtilis 5′-nucleotidases with various functions and substrate specificities

    In Escherichia coli, nagD, yrfG, yjjG, yieH, yigL, surE, and yfbR encode 5′-nucleotidases that hydrolyze the phosphate group of 5′-nucleotides. In Bacillus subtilis, genes encoding 5′-nucleotidase have remained t...

    Ayako Terakawa, Ayane Natsume, Atsushi Okada, Shogo Nishihata, Junko Kuse, Kosei Tanaka, Shinji Takenaka, Shu Ishikawa and Ken-ichi Yoshida

    BMC Microbiology 2016 16:249

    Published on: 26 October 2016

  8. Research article

    In vivo functional and molecular characterization of the Penicillin-Binding Protein 4 (DacB) of Pseudomonas aeruginosa

    Community and nosocomial infections by Pseudomonas aeruginosa still create a major therapeutic challenge. The resistance of this opportunist pathogen to β-lactam antibiotics is determined mainly by production of ...

    Cristian Gustavo Aguilera Rossi, Paulino Gómez-Puertas and Juan Alfonso Ayala Serrano

    BMC Microbiology 2016 16:234

    Published on: 6 October 2016

  9. Research article

    The MarR-like protein PchR (YvmB) regulates expression of genes involved in pulcherriminic acid biosynthesis and in the initiation of sporulation in Bacillus subtilis

    Cyclodipeptides and their derivatives constitute a large class of peptide natural products with noteworthy biological activities. In some yeasts and bacterial species, pulcherriminic acid derived from cyclo-L-...

    Paola Randazzo, Anne Aubert-Frambourg, Alain Guillot and Sandrine Auger

    BMC Microbiology 2016 16:190

    Published on: 20 August 2016

  10. Research article

    Corynebacterium glutamicum possesses β-N-acetylglucosaminidase

    In Gram-positive Corynebacterium glutamicum and other members of the suborder Corynebacterianeae, which includes mycobacteria, cell elongation and peptidoglycan biosynthesis is mainly due to polar growth. C. glut...

    Christian Matano, Stephan Kolkenbrock, Stefanie N. Hamer, Elvira Sgobba, Bruno M. Moerschbacher and Volker F. Wendisch

    BMC Microbiology 2016 16:177

    Published on: 5 August 2016

  11. Research article

    Loss of malic enzymes leads to metabolic imbalance and altered levels of trehalose and putrescine in the bacterium Sinorhizobium meliloti

    Malic enzymes decarboxylate the tricarboxylic acid (TCA) cycle intermediate malate to the glycolytic end-product pyruvate and are well positioned to regulate metabolic flux in central carbon metabolism. Despit...

    Ye Zhang, Laura Anne Smallbone, George C. diCenzo, Richard Morton and Turlough M. Finan

    BMC Microbiology 2016 16:163

    Published on: 26 July 2016

  12. Research article

    Bacteroides fragilis metabolises exopolysaccharides produced by bifidobacteria

    Bacteroides fragilis is the most frequent species at the human intestinal mucosal surface, it contributes to the maturation of the immune system although is also considered as an oppor...

    David Rios-Covian, Isabel Cuesta, Jorge R. Alvarez-Buylla, Patricia Ruas-Madiedo, Miguel Gueimonde and Clara G. de los Reyes-Gavilán

    BMC Microbiology 2016 16:150

    Published on: 15 July 2016

  13. Research article

    Tryptophan catabolism in Pseudomonas aeruginosa and potential for inter-kingdom relationship

    Pseudomonas aeruginosa (Pa) is a Gram-negative bacteria frequently involved in healthcare-associated pneumonia with poor clinical outcome. To face the announced post-antibiotic era due...

    Perrine Bortolotti, Benjamin Hennart, Camille Thieffry, Guillaume Jausions, Emmanuel Faure, Teddy Grandjean, Marion Thepaut, Rodrigue Dessein, Delphine Allorge, Benoit P. Guery, Karine Faure, Eric Kipnis, Bertrand Toussaint and Audrey Le Gouellec

    BMC Microbiology 2016 16:137

    Published on: 8 July 2016

  14. Research article

    Biochemical and spectroscopic characterization of purified Latex Clearing Protein (Lcp) from newly isolated rubber degrading Rhodococcus rhodochrous strain RPK1 reveals novel properties of Lcp

    Biodegradation of rubber (polyisoprene) is initiated by oxidative cleavage of the polyisoprene backbone and is performed either by an extracellular rubber oxygenase (RoxA) from Gram-negative rubber degrading b...

    Sirimaporn Watcharakul, Wolf Röther, Jakob Birke, Kamontam Umsakul, Brian Hodgson and Dieter Jendrossek

    BMC Microbiology 2016 16:92

    Published on: 23 May 2016

  15. Research article

    Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics

    The emergence of antibiotic resistant pathogenic bacteria has reduced our ability to combat infectious diseases. At the same time the numbers of new antibiotics reaching the market have decreased. This situati...

    Verena Hoerr, Gavin E. Duggan, Lori Zbytnuik, Karen K. H. Poon, Christina Große, Ute Neugebauer, Karen Methling, Bettina Löffler and Hans J. Vogel

    BMC Microbiology 2016 16:82

    Published on: 10 May 2016

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