Clinical microbiology and vaccines

Section edited by Igor Mokrousov and Raffaele Zarrilli

This section aims to publish studies looking at all aspects of clinical microbiology, including virology, epidemiology, antimicrobial resistance, vaccines and immune responses.

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  1. Research article

    Clonality, outer-membrane proteins profile and efflux pump in KPC- producing Enterobacter sp. in Brazil

    Carbapenems resistance in Enterobacter spp. has increased in the last decade, few studies, however, described the mechanisms of resistance in this bacterium. This study evaluated clonality and mechanisms of carba...

    Juliana Ferraz Rosa, Camila Rizek, Ana Paula Marchi, Thais Guimaraes, Lourdes Miranda, Claudia Carrilho, Anna S Levin and Silvia F Costa

    BMC Microbiology 2017 17:69

    Published on: 17 March 2017

  2. Research article

    Molecular characterization of invasive capsule null Neisseria meningitidis in South Africa

    The meningococcal capsule is an important virulence determinant. Unencapsulated meningococci lacking capsule biosynthesis genes and containing the capsule null locus (cnl) are predominantly non-pathogenic. Rare c...

    Karistha Ganesh, Mushal Allam, Nicole Wolter, Holly B. Bratcher, Odile B. Harrison, Jay Lucidarme, Ray Borrow, Linda de Gouveia, Susan Meiring, Monica Birkhead, Martin C. J. Maiden, Anne von Gottberg and Mignon du Plessis

    BMC Microbiology 2017 17:40

    Published on: 21 February 2017

  3. Research article

    The respiratory microbiome in bronchial mucosa and secretions from severe IgE-mediated asthma patients

    The bronchial microbiome in chronic lung diseases presents an abnormal pattern, but its microbial composition and regional differences in severe asthma have not been sufficiently addressed. The aim of the stud...

    Laura Millares, Guadalupe Bermudo, Vicente Pérez-Brocal, Christian Domingo, Marian Garcia-Nuñez, Xavier Pomares, Andrés Moya and Eduard Monsó

    BMC Microbiology 2017 17:20

    Published on: 19 January 2017

  4. Research article

    Identification of a novel bovine enterovirus possessing highly divergent amino acid sequences in capsid protein

    Bovine enterovirus (BEV) belongs to the species Enterovirus E or F, genus Enterovirus and family Picornaviridae. Although numerous studies have identified BEVs in the feces of cattle with diarrhea, the pathogenic...

    Shinobu Tsuchiaka, Sayed Samim Rahpaya, Konosuke Otomaru, Hiroshi Aoki, Mai Kishimoto, Yuki Naoi, Tsutomu Omatsu, Kaori Sano, Sachiko Okazaki-Terashima, Yukie Katayama, Mami Oba, Makoto Nagai and Tetsuya Mizutani

    BMC Microbiology 2017 17:18

    Published on: 17 January 2017

  5. Researc article

    A novel quantitative PCR detects Babesia infection in patients not identified by currently available non-nucleic acid amplification tests

    Ticks transmit Babesia microti, the causative agents of babesiosis in North America and Europe. Babesiosis is now endemic in Northeastern USA and affects people of all ages. Babesia species infect erythrocytes an...

    Lavoisier Akoolo, Samantha Schlachter, Rasel Khan, Laura Alter, Albert D. Rojtman, Kristine Gedroic, Purnima Bhanot and Nikhat Parveen

    BMC Microbiology 2017 17:16

    Published on: 14 January 2017

  6. Research article

    Methicillin resistance and virulence genes in invasive and nasal Staphylococcus epidermidis isolates from neonates

    Staphylococcus epidermidis is an opportunistic pathogen involved in hospital-acquired infections, particularly in those related to medical devices. This study characterized 50 genetica...

    Vivian Carolina Salgueiro, Natalia Lopes Pontes Iorio, Marcelle Cristina Ferreira, Raiane Cardoso Chamon and Kátia Regina Netto dos Santos

    BMC Microbiology 2017 17:15

    Published on: 13 January 2017

  7. Methodology article

    Evaluation of a broad-ranging and convenient enzyme-linked immunosorbent assay using the lysate of infected cells with five serotypes of Orientia tsutsugamushi, a causative agent of scrub typhus

    Scrub typhus is a mite-borne rickettsiosis caused by infection of Orientia tsutsugamushi, which is endemic to several Asia-Pacific Rim countries, including Japan. Although micro-indirect immunofluorescent assay (...

    Motohiko Ogawa, Masaaki Satoh, Masayuki Saijo and Shuji Ando

    BMC Microbiology 2017 17:7

    Published on: 5 January 2017

  8. Research article

    Emerging Helicobacter pylori levofloxacin resistance and novel genetic mutation in Nepal

    The prevalence of Helicobacter pylori antibiotic susceptibility in the Nepalese strains is untracked. We determined the antibiotic susceptibility for H. pylori and analyzed the presence of genetic mutations assoc...

    Muhammad Miftahussurur, Pradeep Krishna Shrestha, Phawinee Subsomwong, Rabi Prakash Sharma and Yoshio Yamaoka

    BMC Microbiology 2016 16:256

    Published on: 4 November 2016

  9. Research article

    Characteristic of Enterococcus faecium clinical isolates with quinupristin/dalfopristin resistance in China

    Quinupristin/dalfopristin (Q/D) is a valuable alternative antibiotic to vancomycin for the treatment of multi-drug resistant Enterococcus faecium infections. However, resistance to Q/D in E. faecium clinical isol...

    Shanshan Wang, Yinjuan Guo, Jingnan Lv, Xiuqin Qi, Dan Li, Zengqiang Chen, Xueqing Zhang, Liangxing Wang and Fangyou Yu

    BMC Microbiology 2016 16:246

    Published on: 21 October 2016

  10. Research article

    Chimeric epitope vaccine against Leptospira interrogans infection and induced specific immunity in guinea pigs

    Leptospirosis is an important reemerging zoonosis, with more than half a million cases reported annually, and is caused by pathogenic Leptospira species. Development of a universal vaccine is one of the major str...

    Xu’ai Lin, Guohui Xiao, Dongjiao Luo, Liangliang Kong, Xu Chen, Dexter Sun and Jie Yan

    BMC Microbiology 2016 16:241

    Published on: 14 October 2016

  11. Research article

    Longitudinal survey of Clostridium difficile presence and gut microbiota composition in a Belgian nursing home

    Increasing age, several co-morbidities, environmental contamination, antibiotic exposure and other intestinal perturbations appear to be the greatest risk factors for C. difficile infection (CDI). Therefore, elde...

    Cristina Rodriguez, Bernard Taminiau, Nicolas Korsak, Véronique Avesani, Johan Van Broeck, Philippe Brach, Michel Delmée and Georges Daube

    BMC Microbiology 2016 16:229

    Published on: 1 October 2016

  12. Research article

    Investigation of Streptococcus salivarius-mediated inhibition of pneumococcal adherence to pharyngeal epithelial cells

    Pneumococcal adherence to the nasopharyngeal epithelium is a critical step in colonisation and disease. The probiotic bacterium, Streptococcus salivarius, can inhibit pneumococcal adherence to epithelial cells in...

    Jayne Manning, Eileen M. Dunne, Philip A. Wescombe, John D. F. Hale, E. Kim Mulholland, John R. Tagg, Roy M. Robins-Browne and Catherine Satzke

    BMC Microbiology 2016 16:225

    Published on: 29 September 2016

  13. Research article

    Production of infectious HCV genotype 1b virus in cell culture using a novel Set of adaptive mutations

    Despite the high prevalence of genotype 1b hepatitis C virus (HCV) among patients, a cell culture system that permits entire viral life cycle of genotype 1b isolates is limited. To develop a cell-cultured hepa...

    Ken-ichi Mori, Akihiro Matsumoto, Noboru Maki, Yuki Ichikawa, Eiji Tanaka and Shintaro Yagi

    BMC Microbiology 2016 16:224

    Published on: 27 September 2016

  14. Research article

    Development and performance evaluation of a recombinase polymerase amplification assay for the rapid detection of group B streptococcus

    Despite the implementation of prevention guidelines, group B Streptococcal (GBS) infection remains a leading cause of sepsis, pneumonia, and meningitis, resulting in significant neonatal morbidity and mortalit...

    Christina Clarke, Louise O’Connor, Heather Carré-Skinner, Olaf Piepenburg and Terry J. Smith

    BMC Microbiology 2016 16:221

    Published on: 22 September 2016

  15. Research article

    Diphenyl diselenide derivatives inhibit microbial biofilm formation involved in wound infection

    Organoselenium compounds have antimicrobial activity against some bacteria and fungi; furthermore, the antioxidant activity of diselenides has been demonstrated. The aim of the present work was to examine the ...

    Luca Sancineto, Miranda Piccioni, Stefania De Marco, Rita Pagiotti, Vanessa Nascimento, Antonio Luiz Braga, Claudio Santi and Donatella Pietrella

    BMC Microbiology 2016 16:220

    Published on: 21 September 2016

  16. Methodology article

    Time-kill curve analysis and pharmacodynamic modelling for in vitro evaluation of antimicrobials against Neisseria gonorrhoeae

    Gonorrhoea is a sexually transmitted infection caused by the Gram-negative bacterium Neisseria gonorrhoeae. Resistance to first-line empirical monotherapy has emerged, so robust methods are needed to evaluate the...

    Sunniva Foerster, Magnus Unemo, Lucy J. Hathaway, Nicola Low and Christian L. Althaus

    BMC Microbiology 2016 16:216

    Published on: 17 September 2016

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